Study on the Association Between Squamous Cell Carcinoma of Larynx and HPV by PCR

Introduction: Abroad epidemiologic studies have suggested human papillomavirus (HPV) to be an etiological agent in Squamous cell carcinoma (SCC) of larynx. In this study we investigated the frequency of HPV 16 infection in various neoplastic and non-neoplastic laryngeal tissue. Materials and Methods: The study was done on 55 cases of laryngeal SCC, 10 cases of dysplastic and 5 cases of normal tissues were analyzed by polymerase chain reaction (PCR) for the presence of HPV 16. Results: None of the five normal and ten dysplastic laryngeal tissues showed the presence of HPV. Seven of fifty-five Squamous cell carcinoma of larynx (12.7%) were positive for HPV type 16. Conclusions: The results suggested that HPV DNA has a major role in squamous cell carcinoma of larynx