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July 1, 1986Cardiovascular Research

Cardiac performance returned to near normal when pyruvate or ribose was used as substrate, despite further depressed adenine nucleotide and ATP concentrations.

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Why the study?

Does perfusion with pyruvate or ribose improve cardiac performance in cardiomyopathic and acidotic hamster hearts compared to glucose?

Population

Cardiomyopathic Syrian hamster hearts (240 days old) and healthy acidotic Syrian hamster hearts

Comparison

Perfusion with pyruvate or ribose as substrate vs Perfusion with glucose as substrate

Design

Preclinical

Authors

JWJoan Wikman‐CoffeltRSRichard E. SieversWPWilliam W. Parmley

Discussion

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Overview

Pyruvate or ribose may sustain cardiac performance independent of ATP in this model; leaves open translation to human cardiomyopathy or acidosis.

Structured PICO

Does perfusion with pyruvate or ribose improve cardiac performance in cardiomyopathic and acidotic hamster hearts compared to glucose?

P
Population
Cardiomyopathic Syrian hamster hearts (240 days old) and healthy acidotic Syrian hamster hearts
I
Intervention
Perfusion with pyruvate or ribose as substrate
C
Comparator
Perfusion with glucose as substrate
O
Outcome
Cardiac performance (developed pressure, dP/dt) and mitochondrial activity (ATP, adenine nucleotides)surrogate

In a hamster model of cardiomyopathy and acidosis, cardiac performance is maintained by mitochondrial activity supported by pyruvate or ribose, independent of total ATP concentrations until critically low levels are reached.

Cite This Study

Wikman‐Coffelt et al. (1986) studied this question.

synapsesocial.com/papers/6a83871fdaf812a7fbcd7ccdhttps://doi.org/10.1093/cvr/20.7.471
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