Why the study?
Do verapamil, prenylamine, Dibenamine, propranolol, and prostaglandin E1 reduce the severity of heart lesions in UM-X7.1 cardiomyopathic hamsters?
Do verapamil, prenylamine, Dibenamine, propranolol, and prostaglandin E1 reduce the severity of heart lesions in UM-X7.1 cardiomyopathic hamsters?
Calcium antagonists, adrenergic blockers, and prostaglandin E1 prevent the development of severe heart lesions in a hamster model of cardiomyopathy.
May inform drug selection in cardiomyopathy research; leaves open translation from hamster model to patients.
Verapamil and prenylamine, which antagonize calcium influx into heart muscle cells, Dibenamine and propanolol, alpha and beta adrenergic bockers, respectively, and prostaglandin E1, which acts on permeability of cell membranes and on adrenergic neurotransmission, were all shown to markedly reduce the severity of heart lesions in UM-X7.1 cardiomyopathic hamsters. The beneficial effects of these compounds seen essentially preventive, in that they do not afford protection for fully developed skeletal muscle lesions. The occurrence of the pathologic changes in the myocardium coincides with an increased adrenergic nerve activity, and it is believed that these drugs function mainly by decreasing calcium conductivity across the sarcolemmal membranes of cardiocytes.
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Jasmin et al. (1979) studied this question.
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