Why the study?
Viral envelope glycoproteins direct viral entry and host immune targeting, but the mechanism by which MARCH cellular proteins disrupt their trafficking and virion incorporation required investigation.
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This basic science research provides insights into how host cell factors antagonize viral replication by targeting viral glycoproteins.
Viral envelope glycoproteins are an important structural component on the surfaces of enveloped viruses that direct virus binding and entry and also serve as targets for the host adaptive immune response. In this study, we investigate the mechanism of action of the MARCH family of cellular proteins that disrupt the trafficking and virion incorporation of viral glycoproteins across several virus families. This research provides novel insights into how host cell factors antagonize viral replication, perhaps opening new avenues for therapeutic intervention in the replication of a diverse group of highly pathogenic enveloped viruses.
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Lun et al. (2021) studied this question.
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