Role of endogenous adenosine as a predictive marker of vasoplegia during cardiopulmonary bypass and postoperative severe systemic inflammatory response

François Kerbaul; Frédéric Collart; Roch Giorgi; Ibrahim Zouher; Jean‐Claude Guillen; Jean‐Marie Gil; A Saadjian; Annick Mouly-Bandini; Gilbert Habib; F. Gouin; Régis Guieu

doi:10.1097/01.ccm.0000201005.34203.50

February 22, 2006Critical Care Medicine

Role of endogenous adenosine as a predictive marker of vasoplegia during cardiopulmonary bypass and postoperative severe systemic inflammatory response

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Key Points

To determine whether circulating endogenous adenosine levels correlate with intraoperative vasoplegia and severe systemic inflammatory response syndrome in patients undergoing cardiopulmonary bypass.
Conducted a prospective comparative observational study of 35 patients undergoing aortic valve replacement requiring cardiopulmonary bypass at a tertiary care center.
Measured adenosine plasma levels at baseline, intraoperatively, and immediately post-surgery, correlating them with hemodynamic status and clinical outcomes.
Adenosine plasma levels were markedly elevated in the seven patients who developed vasoplegia and severe postoperative SIRS compared to those without (1.6 µmol/L [0.2–2.6] vs. 0.4 µmol/L [0.1–1.0]) at baseline and during surgery.
Mean arterial pressure exhibited a strong inverse correlation with mean arterial adenosine plasma levels (Pearson's R = -0.66; p < 0.001).
Patients with higher circulating adenosine concentrations required significantly longer durations of mechanical ventilation and extended intensive care unit stays.

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Implication

Prospective observational study reveals elevated plasma adenosine correlates with vasoplegia in cardiac surgery patients, suggesting a key role in post-bypass systemic inflammatory response.

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Kerbaul et al. (2006) studied this question.

synapsesocial.com/papers/6a8388d55e7ab8df27951375 https://doi.org/10.1097/01.ccm.0000201005.34203.50

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Role of endogenous adenosine as a predictive marker of vasoplegia during cardiopulmonary bypass and postoperative severe systemic inflammatory response

Key Points

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Implication

Discussion

Cite This Study

Role of endogenous adenosine as a predictive marker of vasoplegia during cardiopulmonary bypass and postoperative severe systemic inflammatory response

Key Points

No abstract yet

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Implication

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Cite This Study

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