Why the study?
Does the AutoCapture function reliably and safely determine pacing thresholds in patients with non-low polarization leads?
Does the AutoCapture function reliably and safely determine pacing thresholds in patients with non-low polarization leads?
The off-label use of the AutoCapture function with non-low polarization leads is associated with erroneous polarization measurements and incorrect pacing threshold determination, posing a safety risk.
May warrant caution with off-label AutoCapture in non-low polarization leads; hypothesis-generating for algorithm reliability.
The AutoCapture (AC) function of new pacemakers (PM) from St Jude Medical (SJM) was originally recommended for use with low polarization (LP) ventricular leads only.However, recent reports have encouraged the use of the AC function with various leads, including those lacking a special LP design. The objective of this study was to analyze the reliability and safety of the AC algorithm application with different types of pacing leads. The study group comprised 30 consecutive patients with AC PMs connected to three different types of non-LP leads. Ten patients with SJM LP leads served as the control group. The study protocol included a complete AC function test using four different pulse widths (PW). The pacing threshold was independently assessed by a manual/semiautomatic check. Erratic behavior of polarization measurements with increasing PWs was demonstrated in 43% (n = 13) of the study group. Invalid polarization measurements resulted in erroneous algorithm recommendation to apply AC function in 17% (n = 5) of the study patients. Subsequent AC function activation lead to incorrect threshold determination due to missed noncapture in three patients. AC function should be applied with caution with non-LP leads. "Off label" use of these leads may cause erroneous polarization signal measurements which, in some cases, may result in incorrect pacing threshold determination, rendering a potential risk to dependent patients.
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Luria et al. (2004) studied this question.
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