Key result
Combined TyG-SIRI index predicts severe coronary stenosis in ACS with an AUC of ~0.74.
Why the study?
Early identification of high-risk CAD in ACS patients is critical, motivating investigation of combined TyG and SIRI indices for assessing coronary stenosis severity as a cost-effective risk stratification strategy.
Does the combined TyG and SIRI index associate with coronary artery stenosis severity in ACS patients?
Cohort (n=415)
No
Does the combined TyG and SIRI index associate with coronary artery stenosis severity in ACS patients?
Effect estimate: AUC 0.744 (95% CI 0.698-0.790)
p-value: p=<0.001
The combination of TyG and SIRI indices provides a non-invasive, cost-effective marker for assessing coronary stenosis severity in patients with acute coronary syndrome.
Combined TyG-SIRI may aid ACS risk stratification; hypothesis-generating and requires prospective validation before practice change.
BACKGROUND: Early identification of high-risk individuals for coronary artery disease (CAD) is critical, especially in acute coronary syndrome (ACS) patients who face elevated risks of adverse cardiovascular events and are in need of intensified secondary prevention. This study aimed to investigate the combined value of the triglyceride-glucose (TyG) index-a surrogate marker of insulin resistance-and the systemic inflammatory response index (SIRI), calculated as (neutrophil count × monocyte count)/ lyphocyte count, in assessing coronary artery stenosis severity, proposing a cost-effective strategy for risk stratification in ACS management. METHODS: A retrospective cohort study included 415 ACS patients diagnosed by coronary angiography at Beijing University of Chinese Medicine Third Affiliated Hospital (June 2021-February 2024). Patients were stratified into low stenosis (Gensini score < 34, n = 204) and high stenosis (Gensini score ≥ 34, n = 211) groups based on the median Gensini score. Clinical parameters and inflammatory markers were analyzed using logistic regression and ROC curves. RESULTS: High stenosis group showed significantly higher TyG (1.95 vs. 1.42, P < 0.001) and SIRI (1.07 vs. 0.75, P < 0.001) than the low stenosis group. Both indices independently associated with severe stenosis (OR = 3.094 and 2.064, P < 0.001). The combined TyG-SIRI model achieved an AUC of 0.744 (sensitivity 61.61%, specificity 72.06%), outperforming individual indices (TyG: 0.715; SIRI: 0.666; Delong's test P < 0.05). CONCLUSION: The combination of TyG and SIRI is strongly associated with coronary stenosis severity in ACS patients, suggesting its potential as a clinically feasible, non-invasive indicator for early risk stratification.
No takes yet. Share an insight, caveat, or question.
Zhang et al. (2025) conducted a cohort in Acute coronary syndrome (ACS) (n=415). Combined triglyceride-glucose (TyG) index and systemic inflammatory response index (SIRI) vs. Individual indices (TyG or SIRI alone) was evaluated on Severe coronary artery stenosis (Gensini score ≥ 34) (AUC 0.744, 95% CI 0.698-0.790, p=<0.001). The combined triglyceride-glucose (TyG) index and systemic inflammatory response index (SIRI) model was strongly associated with severe coronary artery stenosis in patients with acute coronary syndrome, achieving an AUC of 0.744.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: