The relative efficacy and toxicity of cytotoxic drugs in those over the age of 65 years is an important but still controversial and under‐researched area. Age‐related physiological changes, particularly changes in renal function, may lead to increased toxicity in the elderly. However, treatment policies chosen to reduce toxicity may compromise therapeutic results, creating the impression that chemotherapy may be less effective in the elderly. An individualised approach to dosing of cytotoxic agents is required in this age group.
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Siderov et al. (1998) studied this question.
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