Studies on the Mechanism of Diuresis After Relief of Urinary-tract Obstruction

Case Studies1 January 1967Studies on the Mechanism of Diuresis After Relief of Urinary-tract ObstructionSHAUL G. MASSRY, M.D., LEWIS I. SCHAINUCK, M.D., CARL GOLDSMITH, M.D., GEORGE E. SCHREINER, M.D., F.A.C.P.SHAUL G. MASSRY, M.D.Search for more papers by this author, LEWIS I. SCHAINUCK, M.D.Search for more papers by this author, CARL GOLDSMITH, M.D.Search for more papers by this author, GEORGE E. SCHREINER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-1-149 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince the first studies of the diuresis after relief of urinary-tract obstruction by Wilson, Reisman, and Moyer (1), this phenomenon has received much attention. Earley (2) reported a patient in whom impaired response to anti-diuretic hormone appeared to be the major cause of the diuresis. Bricker and associates (3) studied four patients in whom impaired proximal tubular sodium reabsorption was prominent. Maher, Schreiner, and Waters (4) more recently described a patient in whom they showed that diuresis was due to the osmotic effect of urea.In the present report, observations are presented that indicate that the diuresis that followed the...References1. WILSONREISMANMOYER BDDCA: Fluid balance in the urological patient: disturbances in the regulation of the excretion of water and sodium salts following decompression of the urinary bladder. J. Urol. 66: 805, 1951. CrossrefMedlineGoogle Scholar2. EARLEY LE: Extreme polyuria in obstructive uropathy: report of a case of "water-losing nephritis" in an infant, with discussion of polyuria. New Eng. J. Med. 255: 600, 1956. CrossrefMedlineGoogle Scholar3. BRICKERSHWAYRIREARDANKELLOGMERRILLHOLMES NSEIJBDJPJH: An abnormality in renal function resulting from urinary tract obstruction. Amer. J. Med. 28: 554, 1957. 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YUNISBERCOVITCHSTEINLEVITTGOLDSTEIN SLDDRMMFMH: Renal tubular effects of hydrocortisone and aldosterone in normal hydropenic man: comment on sites of action. J. Clin. Invest. 43: 1668, 1964. CrossrefMedlineGoogle Scholar20. CRABBE J: The role of aldosterone in the renal concentration mechanism in man. Clin. Sci. 23: 39, 1962. MedlineGoogle Scholar21. RIVERANURKOSANTOSDIES ABEF: Studies on the localization of aldosterone action on the renal tubule. Steroids 1: 91, 1963. CrossrefGoogle Scholar22. THORNSHEPPARDMORSEREDDYBEIGELMANRENOLD GWRHWIWJPMAE: Comparative action of aldosterone and 9-α-fluorohydrocortisone in man. Ann. N. Y. Acad. Sci. 61: 609, 1955. CrossrefMedlineGoogle Scholar23. ANSLOWWESSON WPLG: Effect of sustained graded urea diuresis on water and electrolyte excretion. Amer. J. Physiol. 180: 605, 1955. CrossrefMedlineGoogle Scholar24. RAISZSCHEER LGRL: Studies on the renal concentrating mechanism. II. Effect of small acute changes in solute excretion. J. Clin. Invest. 38: 1, 1959. CrossrefMedlineGoogle Scholar25. LEVITINGOODMANPIGEONEPSTEIN HAGFH: Composition of the renal medulla during water diuresis. J. Clin. Invest. 41: 1145, 1962. CrossrefMedlineGoogle Scholar26. BERLYNE GM: Distal tubular function in chronic hydronephrosis. Quart. J. Med. 30: 339, 1961. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: SHAUL G. MASSRY, M.D.; LEWIS I. SCHAINUCK, M.D.; CARL GOLDSMITH, M.D.; GEORGE E. SCHREINER, M.D., F.A.C.P.Affiliations: Washington, D. C.From the Georgetown Medical Division, District of Columbia General Hospital, and the Department of Internal Medicine, Georgetown University Medical School, Washington, D. C.This study was supported in part by research career program award 1-K3-AM-31, 183-01, the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to Carl Goldsmith, M.D., Box 303, D. C. General Hospital, Washington, D. C. 20003. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRole of Percutaneous Nephrostomy in Improving Quality of Life in Advanced Carcinoma Cervix Presenting with Obstructive UropathyInsuffisance rénale aiguë obstructive de l’adulte en réanimation : prise en charge et facteurs pronostiquesAcute Kidney Injury and Postobstructive Diuresis Caused by a 4 mm Urinary CalculusSevere post-renal acute kidney injury, post-obstructive diuresis and renal recoveryObstructive UropathyManagement of extreme azotemia from urinary tract obstruction without dialysis. 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