Nucleic Acid Based Biosensors for Clinical Applications

Biosensors are analytical tools which have applications in diverse fields like diagnostics, disease monitoring etc. Since last few decades, nucleic acid based analytics have gained much interest in detection and monitoring of various clinical manifestations. Nucleic acid based biosensors (NABs) are preferred choice due to their high sensitivity and selectivity. Novel synthetic probes (PNA, Aptamer) have been exploited to fabricate point-of-care NABs. Due to flexible and low-cost fabrication, they are evolving as rapid and reliable tools in clinical diagnostics market. In this review, we focus on different transducer platform (Optical, Electrochemical, Piezoelectrical) based NABs which have been implemented to detect broad spectrum of metabolic and infectious diseases. A few commercialized NAB products are also summarized.