AIM: The aim of this study was to evaluate the risk factor of gallstone occurrence after distal gastrectomy (DG) for gastric cancer. METHODS: Relevant documents published from 2000 to 2016 were retrieved in PubMed, Web of Knowledge, and Ovid's database, and a metaanalysis was performed with RevMan 5.0 software for odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: Eight studies met the final inclusion criteria. From the pooled analyses, nonphysiological reconstruction (OR = 1.51; 95% CI = 1.10-2.08; P = 0.01) and vagus nerve resection (OR = 2.79; 95% CI = 1.57-4.96; P = 0.0005) were significantly associated with increased risk of gallstone after DG. CONCLUSION: Our analysis indicated that digestive tract reconstruction and vagus nerve resection were strongly and consistently associated with gallstone formation after DG.
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