Why the study?
Patients with CAD and diabetes are at high cardiovascular risk due to potentiated thrombogenesis, and reducing thrombus formation is key to improving their prognosis.
Does antithrombotic therapy (aspirin and rivaroxaban) reduce the risk of cardiovascular events and all-cause death in patients with CAD and diabetes?
Does antithrombotic therapy (aspirin and rivaroxaban) reduce the risk of cardiovascular events and all-cause death in patients with CAD and diabetes?
This review highlights the importance of modern antithrombotic therapy, including low-dose rivaroxaban and aspirin, in reducing mortality and cardiovascular events in high-risk patients with CAD and diabetes.
Answers are grounded in this paper and cite their sources.
Emphasizes antithrombotic focus in CAD-diabetes overlap; leaves open optimal regimens for this high-risk population.
Patients with coronary artery disease (CAD) and diabetes are identified as a high cardiovascular risk group both in Russia and abroad. Having similar paths of development and progression of atherosclerosis and atherothrombosis, these diseases potentiate each other's thrombogenesis mechanisms. As a result, cardiovascular ischemic events occur, making a significant contribution to the mortality rates of this group of patients. Influencing the risk of thrombus formation is one of the key links on the way to improving the prognosis of patients with CAD and diabetes. Modern antithrombotic therapy, including not only the antiplatelet agent aspirin, but also the anticoagulant rivaroxaban at a dose of 2,5 mg, allows for the maximum impact on the development of atherothrombosis, thereby reducing the risks of cardiovascular events and all-cause death. The aim of the review was to analyze the potential of reducing the all-cause death risk by prescribing the main drug groups that are part of the therapy of patients with CAD and diabetes.
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Некрасов et al. (2024) studied this question.
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