Age-related changes of serum gonadotropin levels in normal men were studied using a specific double-antibody radioimmunoassay of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). The subjects were divided into age groups of 5-yr intervals from 0 to 20 yr, of 10-yr intervals from 21 to 70 yr and the final or oldest group of ages after 71 yr. Normal adult serum LH and FSH levels were attained after 16 yr of age and significant elevations in serum gonadotropin levels were first noted in the fifth decade of life. However, the degree of the elevation of serum gonadotropin levels in the aged men was relatively small, when compared with that observed in women of the same age group. The difference is considered to be due to the fact that the decline in gonadal function with advanced age in the male is not as drastic as in the female.
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Isurugi et al. (1974) studied this question.
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