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The enantioseparation of 442 clinically used racemic drugs by high‐performance liquid chromatography on commercial chiral stationary phases (CSPs) available in 2006 is reviewed. The CSPs are briefly described in Part I of this work. The data was extracted and compiled from the ChirBase database (Marseille, France). All the drugs included are listed according to the Anatomical Therapeutic Chemical (ATC) classification that defined thirteen therapeutic classes. Only positive results are reported and, for a given CSP type, only the set of analytical conditions providing the best enantioselectivity is provided. The analyst can find at a glance the optimal CSP column and its supplier, as well as the suitable mobile phase allowing for an efficient enantioresolution of a racemic drug. Given the amount of data, Part I of this compilation included the technical and molecular description of exactly one hundred commercial CSPs and the six opening ATC classes with 211 enantiomeric drugs arranged from Class 1: “Alimentary tract and metabolism” to Class 6: “Cardiovascular system.” Part II includes the 231 remaining chiral drugs arranged in the seven remaining classes from Class 7: “Dermatologicals” to Class 12: “Sensory Organs” and Class 13: “Various Drugs.” The final index refers to the two parts.
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Félix et al. (2008) studied this question.
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