Population
EAhy 926 endothelial cells
Comparison
UTP stimulation, with or without cycloheximide… vs Unstimulated cells or cells without inhibitors
Design
Preclinical
Authors
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Hypothesis-generating for endothelial MAP kinase regulation; leaves open in vivo relevance and therapeutic targeting.
The termination of MAP kinase activity in response to UTP in endothelial cells involves receptor desensitization and phosphatase induction, with cyclic AMP playing a role after an initial protein-synthesis step.
Graham et al. (1996) studied this question.
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