Answers are grounded in this paper and cite their sources.
Retapamulin had the lowest rate of spontaneous mutations by single-step passaging and the lowest parent and selected mutant MICs by multistep passaging among all drugs tested for all Staphylococcus aureus strains and three Streptococcus pyogenes strains which yielded resistant clones. Retapamulin has a low potential for resistance selection in S. pyogenes, with a slow and gradual propensity for resistance development in S. aureus.
No takes yet. Share an insight, caveat, or question.
Kosowska-Shick et al. (2006) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: