NF45 and NF90 Regulate HS4-dependent Interleukin-13 Transcription in T Cells

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Population

Human CD4(+) Jurkat T cells and primary murine Th2 cells (from wild-type, NF45(+/-), or NF90(+/-) mice)

Comparison

Transfection of HS4-IL13 reporter vectors and… vs Wild-type vs NF45(+/-) vs NF90(+/-) cells

Design

Preclinical

Authors

Discussion

NF45/NF90 emerge as IL13 regulators in T-cell activation; leaves open therapeutic targeting in allergic disease.

Population

Human CD4(+) Jurkat T cells and primary murine Th2 cells (from wild-type, NF45(+/-), or NF90(+/-) mice)

Intervention

Transfection of HS4-IL13 reporter vectors and evaluation of NF45/NF90 binding to HS4-3'

Comparator

Wild-type vs NF45(+/-) vs NF90(+/-) cells

Outcome

IL13 proximal promoter activity and IL13 expressionsurrogate

NF45 and NF90 are identified as novel regulators of HS4-dependent human IL13 transcription in response to T cell activation.

Kiesler et al. (2010) studied this question.

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