What question did this study set out to answer?

Review the pathological mechanisms underlying microvascular invasion in hepatocellular carcinoma and evaluate the functional role of circulating tumor cells in forming vascular tumor thrombi.

November 2, 2023Frontiers in GeneticsOpen Access

Circulating tumor cells participate in the formation of microvascular invasion and impact on clinical outcomes in hepatocellular carcinoma

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Authors

BSBin SunShanghai Power Equipment Research Institute WJWeidan JiSecond Military Medical University WWWenchao WangKunming Medical University

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Implication

Narrative review uncovers the role of circulating tumor cells in microvascular invasion in hepatocellular carcinoma, suggesting novel targets to reduce post-surgical recurrence.

Key Points

Review the pathological mechanisms underlying microvascular invasion in hepatocellular carcinoma and evaluate the functional role of circulating tumor cells in forming vascular tumor thrombi.
Synthesized current literature on microvascular invasion and portal vein tumor thrombus development in hepatocellular carcinoma.
Evaluated the molecular interactions between circulating tumor cells and circulating immune cells during tumor thrombus formation.
Identified circulating tumor cells as key biological drivers involved in establishing microvascular invasion and portal vein tumor thrombi.
Described critical interactions between circulating tumor cells and host immune cells that facilitate tumor cell survival and vascular seeding.
Characterized potential preoperative diagnostic biomarkers and therapeutic targets designed to reduce postoperative recurrence and metastasis.

Cite This Study

Sun et al. (2023) studied this question.

synapsesocial.com/papers/6a83cdfc42ccde92f8c57a3d https://doi.org/10.3389/fgene.2023.1265866

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Implication

Narrative review uncovers the role of circulating tumor cells in microvascular invasion in hepatocellular carcinoma, suggesting novel targets to reduce post-surgical recurrence.

Circulating tumor cells participate in the formation of microvascular invasion and impact on clinical outcomes in hepatocellular carcinoma

Discussion

Member takes

Implication

Key Points

Cite This Study

Circulating tumor cells participate in the formation of microvascular invasion and impact on clinical outcomes in hepatocellular carcinoma

Discussion

Member takes

Implication

Key Points

Cite This Study

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