Why the study?
A single hs-cTn sample strategy has been proposed for early risk stratification in patients with possible ACS, requiring sensitivity ≥ 99% for 30-day cardiac events for rapid MI rule-out.
Does a single low high-sensitivity cardiac troponin (hs-cTn) result alone provide ≥ 99% sensitivity for 30-day cardiac events in ED patients with possible ACS?
Does a single low high-sensitivity cardiac troponin (hs-cTn) result alone provide ≥ 99% sensitivity for 30-day cardiac events in ED patients with possible ACS?
A single low high-sensitivity cardiac troponin result alone does not achieve the ≥99% sensitivity required to safely rule out 30-day cardiac events in ED patients with possible ACS.
High-sensitivity cardiac troponin (hs-cTn) testing has enabled shorter time intervals between serial measurements when assessing patients with possible acute coronary syndrome (ACS) with the use of a single sample strategy proposed for early risk stratification. Specifically, a rapid rule-out for myocardial infarction (MI) is suitable for a pathway if the sensitivity for 30-day cardiac events is ≥ 99%. At the population level (n = 131,095 emergency department [ED] patients), low hs-cTn results alone yielded sensitivities < 99%.
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Kavsak et al. (2022) studied this question.
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