The Peptide Synthesis. II. Use of the Phenol Resin for the Peptide Synthesis

The phenol resin is useful as support of the solid phase peptide synthesis. Its use is particularly advantageous for the synthesis of the N-protected peptide fragments, and those which have the intramolecular disulfide bond, such as oxytocin. In the latter case, the application of S-ethylmercapto group as the protector of thiol group of cysteine residue was combined successfully. Oxytocin and physalaemin derivatives were thus synthesized.