Techniques are evaluated for dry-packing columns of Zipax® controlled surface porosity support for high-speed liquid chromatography. The effect of support particle size on column efficiency, number of effective plates per second, Performance Factor and permeability are also described. Plate heights for columns varying from 25–150 cm in length are constant with a preferred modified tap-fill packing procedure. The dilatant (quicksand-like) quality of Zipax® probably accounts for the desirable packing properties and attendant high chromatographic performance of this material.
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J. J. Kirkland (1972) studied this question.