Synthesis of the Palmitoylated and Farnesylated C‐Terminal Lipohexapeptide of the Human N‐Ras Protein by Employing an Enzymatically Removable Urethane Protecting Group

Enzyme-labile urethane protecting groups, which enable the construction of biologically important peptides relevant for cancer research, were used to synthesize characteristic lipidated partial sequences of the human N-Ras protein for the first time. The strategy is sketched below. They are cleaved chemoselectively under very mild conditions (pH 7, 45 °C), and therefore leave extremely sensitive peptide side chains intact.