Nα‐Acetyl‐aminosäure‐methylamide als Modellverbindungen zur Interpretation der ¹³C‐NMR‐Spektren geschützter Peptide

N α ‐Acetyl‐methylamides of Amino Acids as Model Compounds for Interpretation of 13 C‐NMR‐Spectra of Protected Peptides N α ‐Acetyl‐methylamides of differents amino acids have been synthesized as model compounds for amino acid residues in peptides, and 13 C‐n.m.r. spectra have been measured. The three derivatives of peptides Boc‐Glu(OBzl)‐Arg(H + )‐Gly‐Phe‐Phe‐Tyr(Bzl)‐Thr(Bzl)‐Pro‐Lys(Z)‐ Ala‐OBzl (B 21–30). Boc‐Leu‐Tyr(Bzl)‐Leu‐Val‐Cys(SEt)‐Gly‐OH (B 15–20) and Boc‐Ser(Bzl)‐His(Trt)‐Leu‐Val‐Glu(OBzl)‐Ala‐OH (B 9–14) used for the synthesis of insulin B chain are an illustration for the fact that chemical shifts of characteristic amino acid carbon atoms obtained by corresponding model compounds, allow a simple and correct interpretation of peptide derivative spectra.