In 1964, Rallison et al. reported that aminoglutethimide [α-(p-aminophenyl)-α-ethyl-glutarimide, Elipten, Ciba], an anticonvulsant drug, caused goiters and hypothyroidism in children (1). Because of our interest in aminophenyl drugs which are in clinical use and might have antithyroid activity (2, 3), we evaluated aminoglutethimide for such activity.
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Pittman et al. (1966) studied this question.