Coexistent Idiopathic Thrombocytopenic Purpura and Hyperthyroidism

Brief Communication1 August 1967Coexistent Idiopathic Thrombocytopenic Purpura and HyperthyroidismJAMES S. MARSHALL, M.D., AUSTIN S. WEISBERGER, M.D., F.A.C.P., RICHARD P. LEVY, M.D., ROBERT T. BRECKENRIDGE, M.D.JAMES S. MARSHALL, M.D.Search for more papers by this author, AUSTIN S. WEISBERGER, M.D., F.A.C.P.Search for more papers by this author, RICHARD P. LEVY, M.D.Search for more papers by this author, ROBERT T. BRECKENRIDGE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-2-411 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince 1931, sporadic reports have appeared noting an apparent association between hyperthyroidism and idiopathic thrombocytopenic purpura (ITP) (1-4). During a recent survey of our patients with ITP (5), we were impressed with what seemed to be an increased prevalence of hyperthyroidism in this group. This observation prompted us to study patients with ITP who were clinically euthyroid to determine if latent Graves' disease existed in this population.The data reported here indicate that there is indeed an increased prevalence of hyperthyroidism and of latent Graves' disease in patients with ITP. They suggested that these two diseases may share a similar...References1. JACKSON AS: Acute hemorrhagic purpura associated with exophthalmic goiter. JAMA 96: 38, 1931. CrossrefGoogle Scholar2. TOLANDASKEY CGJM: Atypical hemorrhagic purpura occurring with toxic adenoma of the thyroid gland. Mayo Clin. Proc. 6: 597, 1931. Google Scholar3. DENNIG H: Thrombopenische purpura nach jodeinnahme. Munchen. Med. Wschr. 80: 562, 1933. Google Scholar4. FINOCHIETTODELCASTILLO REB: Bocio exoftálmico y purpura hemorrágica trombocitopenica. Semana Med. 43: 1059, 1936. Google Scholar5. BRECKENRIDGEMOORERATNOFF RTRDOD: A study of thrombocytopenia. New histologic criteria for the differentiation of idiopathic thrombocytopenia and thrombocytopenia associated with disseminated lupus erythematosus. Blood. In press. Google Scholar6. WERNER SC: A new and simple test for hyperthyroidism employing 1-triiodothyronine and the 24 hour I131 uptake method. Bull. N. Y. Acad. Med. 31: 137, 1955. MedlineGoogle Scholar7. ODELLWILBERPAUL WDJFWE: Radioimmunoassay of thyrotropin in human serum. J. Clin. Endocr. 25: 1179, 1965. CrossrefMedlineGoogle Scholar8. GREERSMITH MAGE: Method for increasing the accuracy of the radioiodine uptake as a test for thyroid function by the use of desiccated thyroid. J. Clin. Endocr. 14: 1374, 1954. CrossrefGoogle Scholar9. PITT-RIVERSTROTTER RWR: In The Thyroid Gland, vol. 2. Butterworth, Inc., Washington, D. C., 1964, p. 152. Google Scholar10. BLANCK G: Blutbefunde bei hyperthyreose und struma. Deutsch. Arch. Klin. Med. 132: 16, 1920. Google Scholar11. MEANSDEGROOTSTANBURY JHLJJB: The Thyroid and Its Diseases, 3rd ed. McGraw-Hill Book Co., Inc., New York, 1963, p. 191. Google Scholar12. BALDINI M: Idiopathic thrombocytopenic purpura. New Eng. J. Med. 274: 1245, 1301, 1360, 1966. CrossrefMedlineGoogle Scholar13. ADAMS DD: The presence of an abnormal thyroid stimulating hormone in the serum of some thyrotoxic patients. J. Clin. Endocr. 18: 699, 1958. CrossrefGoogle Scholar14. KRISSPLESHAKOVCHIEN JPVJR: Isolation and identification of the long-acting thyroid stimulator and its relation to hyperthyroidism and circumscribed pretibial myxedema. J. Clin. Endocr. 24: 1005, 1964. CrossrefMedlineGoogle Scholar15. MCKENZIE JM: The gamma globulin of Graves' disease: thyroid stimulation by fraction and fragment. Trans. Ass. Amer. Physicians 78: 174, 1965. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cleveland, OhioFrom the Department of Medicine, Western Reserve University School of Medicine, and University Hospitals, Cleveland, Ohio.This study was supported by grant HD 00669, the U. S. Public Health Service, Washington, D. C., and by a grant from The Heart Association of Northeast Ohio, Cleveland, Ohio.Dr. Breckenridge is a George and Anna Bishop Fellow in Medicine.Requests for reprints should be addressed to James S. Marshall, M.D., University Hospitals of Cleveland, Cleveland, Ohio 44106. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHow do we diagnose immune thrombocytopenia in 2018?Mean Platelet Volume in Hyperthyroid Toxic Adenoma Patients after Radioactive 131 I TreatmentHyperthyroidism and Venous Thrombosis: A Casual or Causal Association? 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