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PURPOSE OF REVIEW: To summarize recent findings regarding the effects of inflammation on iron (Fe) metabolism and to review studies detailing the influence of poor Fe status on physical and cognitive performance. RECENT FINDINGS: Hepatic expression and release of hepcidin, a negative regulator of Fe status, is increased by the actions of the inflammatory cytokine interleukin-6. Inflammation associated with chronic disease, obesity, and exercise is associated with elevated interleukin-6 and hepcidin levels, which may result in diminished Fe status. SUMMARY: Decrements in Fe status due to insufficient dietary Fe intake and/or the inflammatory response may degrade physical and cognitive performance. Future studies should clarify whether dietary or other therapeutic interventions to mitigate inflammation attenuate hepcidin-mediated declines in Fe status.
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Gaffney‐Stomberg et al. (2012) studied this question.
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