The use of ene‐reductase (ERED) enzymes for the asymmetric reduction of olefins offers a green, renewable alternative to metal‐catalysed asymmetric reduction. We report herein the first example of an ERED‐catalysed enantiospecific reduction carried out at large scale using a carbonyl reductase (CRED) enzyme in the cofactor recycle. This reaction has been paired with a hydrolase‐mediated regioselective ester hydrolysis to generate a valuable chiral building block using a straightforward one‐pot process.
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Mangan et al. (2012) studied this question.
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