A chip-based platform is reported that is able to detect as few as 10 cancer cells. By developing sub-milliscale sensors that are able to capture slow moving biological targets with high efficiency (see picture; scale bar 50 μm), cancer-specific sequences were detected in crude lysates of leukemia cells. This achievement relied on the development of a new type of molecular probe that improves the solubility and performance of neutral nucleic acids.
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Vasilyeva et al. (2011) studied this question.
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