Population
Isolated portal vein of the rat
Comparison
Felodipine 3 nM vs Lowering of extracellular Ca2+ concentration
Design
Preclinical
Authors
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May modulate vascular stretch sensitivity via Ca2+ blockade; animal data leave open human relevance and require translational studies.
Felodipine specifically inhibits the dynamic myogenic reactivity of rat portal veins, suggesting a negative influence on mechano-electrical coupling.
Bülow et al. (1991) studied this question.
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