Bis(2-cyanoacetohydrazide) as precursors for synthesis of novel azoles/azines and their biological evaluation

The present work deals with the synthesis of 2-cyano- N ′-(3-(2-(2-cyanoacetyl) hydrazinyl) cyclohex-2-en-1-ylidene) acetohydrazide 3 that used as a key precursor in the manufacture of new heterocyclic derivatives, such as pyrazole, pyrane, pyridine, and pyrole incorporating cyclohexene moiety via its reaction with a variety of nucleophilic and electrophilic reagents. The newly synthesized compounds were characterized by their elemental analyses (IR, 1 H-NMR, 13 C-NMR, and Mass spectra) and assessed for their anti-microbial activity.