Peptic ulceration in a dog associated with an islet cell carcinoma of the pancreas and an elevated plasma gastrin level

The history, clinical signs and post‐mortem findings in a 6‐year‐old, male, Boxer dog with peptic ulceration and a tumour derived from islet cells of the pancreas are described. The immunoreactive circulating plasma gastrin in this dog was elevated and measured 360 pg/ml (normal range 23–104 pg/ml). The findings in this dog are similar to those described for Zollinger‐Ellison syndrome in man. It is possible that the pathogenesis of peptic ulceration in this case is similar to that of Zollinger‐Ellison syndrome.