The Maintenance of a constant blood-sugar level of around 100 mg. is one of the most important functions of those organs concerned with the proper fuel regulation of the body. These include, besides the obvious ‘supply’ organs (sensory, central nervous system and digestive tract), most of the organs of internal secretion, and the liver. The co-operative working and interplay of all these tissues to keep the blood sugar at a proper level is one of the most illuminating examples of the constancy of the internal environment of Claude Bernard or homeostasis of Cannon. There are 3 main factors in this regulation besides the obvious absorption of sugar from the intestinal tract. They are a), the rate of oxidation of glucose by the tissues, b), the production of dextrose from other substances by the liver, and c), the storage of glucose as glycogen, fat, and other derivatives.
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Douglas R. Drury (1942) studied this question.