Tricuspid Annular Systolic Velocity to Left Ventricular Outflow Velocity Time Integral Ratio: Proof of Concept Utility Analysis

Figures

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  Figure 1. Linear regression analysis between TA TDI s' and TAPSE. A correlation analysis between the two echocardiographic variables TA TDI s' and TAPSE for our study population was performed. As shown in this figure, showed a strong correlation consistent with previously published data. This data showed that a normal expected correlation between TAPSE and TA TDI values were present to avoid cases of decoupling. TA TDI s' - tricuspid annular tissue Doppler imaging systolic velocity, TAPSE - tricuspid annular plane systolic excursion

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  Figure 2. Box plot analysis Using this analysis we showed TA TDI s’ / LVOT VTI ratio for all three study groups included in this study. This calculated variable was found to be statistically different among the studied groups (group Normal: 0.6 ± 0.1; group PH: 0.5 ± 0.1; and group HF: 0.8 ± 0.3; p < 0.001). TA TDI s' - tricuspid annular tissue Doppler imaging systolic velocity, TAPSE - tricuspid annular plane systolic excursion, PH - pulmonary hypertension, HF - heart failure

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  Figure 3. Receiver operating characteristic (ROC) curves were then produced to test the ability of TA TDI s’/LVOT VTI r to identify patients with an RVOT VTI / LVOT VTI r of 0.8. ROC curve analysis we then used to demonstrate that a TDI s' / LVOT VTI r cutoff value of 0.70 had an 86% sensitivity (95% CI: 42.1 - 99.6) and a 75% specificity (95% CI: 61.0 - 85.3) to discriminate among the study groups (area under the curve: 0.844, P <0.0001). TA TDI s' - tricuspid annular tissue Doppler imaging systolic velocity, LVOT VTI - left ventricular outflow tract velocity time integral ratio, RVOT VTI - right ventricular outflow tract velocity time integral