Organocatalytic cross-aldol reaction of methyl 4-oxobutyrate (2) and a variety of aldehydes 3 followed by reduction with NaBH(4) has provided a one-pot, general and efficient method for the synthesis of 4-(hydroxyalkyl)-gamma-butyrolactones 1 with high diastereo-(dr > 24:1) and enantioselectivity (ee > 99%).
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Hajra et al. (2008) studied this question.
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