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We present the first enantioselective catalysis of the Friedel−Crafts reaction via activation of electron-rich multiple bonds by a chiral Brønsted acid. The reaction of various indole derivatives with a broad range of substituted enecarbamates affords the corresponding Friedel−Crafts products in high yield and enantioselectivity.
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Terada et al. (2006) studied this question.
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