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For studies on heme biosynthesis the biogenetically plausible tripyrroles 1 and 2 bearing 14C and 3H labels have now been synthesized in 20 steps (R = H). Joint incubation of 1 and 2 with hemolyzed duck blood revealed that both tripyrroles can be utilized for the biosynthesis of heme, admittedly with different efficiencies.
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Franck et al. (1977) studied this question.
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