Thyroid replacement therapy may improve painful muscle contractions in patients with a specific variant of dominantly inherited myotonia congenita and coincident hypothyroidism.
May support hypothyroidism screening in myotonia; case reports leave open efficacy in dominantly inherited variants.
We present a family with dominantly inherited myotonia congenita and painful, electrically silent muscle contractions after exertion. In two family members, painful muscle contractions occurred coincident with hypothyroidism, and improved after thyroid replacement therapy. It is probable that this family represents a disease that is similar to but distinct from the dominant form of myotonia congenita.
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Don B. Sanders (1976) studied this question.
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