Why the study?
Are 15-methyl analogues of prostaglandins E2 and F2α effective abortifacients with increased potency and duration of action compared to parent prostaglandins in the second trimester of pregnancy?
Are 15-methyl analogues of prostaglandins E2 and F2α effective abortifacients with increased potency and duration of action compared to parent prostaglandins in the second trimester of pregnancy?
15-methyl analogues of prostaglandins E2 and F2α are highly effective abortifacients with increased potency and duration of action compared to their parent compounds.
May support evaluation of 15-methyl prostaglandin analogues for second-trimester abortion; leaves open need for randomized safety and efficacy trials.
summary The uterine muscle stimulating activities of the 15‐methyl analogues of naturally occurring prostaglandins E 2 , and F 2α , in the second trimester of pregnancy have been investigated. Prostaglandins 15(S) 15 methyl E 2 , methyl ester and 15(S) 15 methyl F 2α , (free acid) when administered by the intravaginal, intra‐amniotic and intramuscular routes are effective abortifacients. The human uterine muscle stimulating potencies and duration of actions of these compounds when compared with the parent prostaglandins E 2 , and F 2α , are greatly increased.
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Karim et al. (1972) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: