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November 12, 2008Journal of NeurochemistryOpen Access

DPDPE, but not TIPP or morphine, induced desensitization and internalization of the deltaOR by activating GRK2 via Src phosphorylation and promoting beta-arrestin recruitment and dephosphorylation.

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Population

Models expressing delta-opioid receptors (deltaOR)

Comparison

DPDPE (delta-opioid receptor agonist) vs TIPP or Morphine

Design

Preclinical

Authors

MHMinhua HongCXChi XuYWYujun Wang

Discussion

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Overview

Agonist-specific deltaOR desensitization via Src-GRK2 should not alter clinical opioid use; leaves open biased signaling targets in tolerance research.

Structured PICO

P
Population
Models expressing delta-opioid receptors (deltaOR)
I
Intervention
DPDPE (delta-opioid receptor agonist)
C
Comparator
TIPP or Morphine
O
Outcome
delta-opioid receptor desensitization and internalizationsurrogate

The study reveals agonist-specific utilization of Src to regulate delta-opioid receptor desensitization and internalization, explaining differential receptor responsiveness to distinct ligands.

Cite This Study

Hong et al. (2008) studied this question.

synapsesocial.com/papers/6a83f899b0b8dfdc4c62e5f9https://doi.org/10.1111/j.1471-4159.2008.05740.x
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