February 1, 1994European Journal of Immunology
Neuronal interferon‐γ immunoreactive molecule: Bioactivities and purification
Population
Rat trigeminal ganglia, macrophages, skeletal muscle cell cultures, and Trypanosoma brucei brucei
Comparison
Purified neuronal interferon-gamma… vs Lymphocyte-derived recombinant IFN-gamma
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for N-IFN-gamma isoforms in immunomodulation; leaves open therapeutic relevance versus recombinant forms pending human studies.
Structured PICO
P
Population
Rat trigeminal ganglia, macrophages, skeletal muscle cell cultures, and Trypanosoma brucei brucei
I
Intervention
Purified neuronal interferon-gamma immunoreactive molecule (N-IFN-gamma)
C
Comparator
Lymphocyte-derived recombinant IFN-gamma
O
Outcome
Protein characteristics (molecular mass) and biological effects (antiviral effects, MHC antigen induction, myoblast proliferation, cholinergic receptor distribution, and Trypanosoma brucei brucei growth)surrogate
N-IFN-gamma is a distinct protein from lymphocyte-derived IFN-gamma but shares structural similarities and biological activities on both parasite and mammalian cells.
Cite This Study
Olsson et al. (1994) studied this question.