Advances and Challenges in Ocular Drug Delivery Systems: A Comprehensive Review

Eye diseases are commonly encountered in day-to-day life, which are cured or prevented through the conventionally used dosage forms like eye drops, ointments.Delivery to the internal parts of the eye still remains troublesome due to the anatomical and protective structure of the eye.The newly developed particulate and vesicular systems like liposomes, pharmacosomes and discomes are useful in delivering the drug for a longer extent and helpful in reaching the systemic circulation.The most recent advancements of the ocular delivery systems provide the delivery of the genes and proteins to the internal structures which were once inaccessible and thus are of great importance in treating the diseases which are caused due to genetic mutation, failure in normal homeostasis, malignancy but also maintaining the physiological function of eye.The review focuses on the developments achieved in this mode of delivery of the drugs along with the pros and cons associated with greater focus on the advanced delivery systems.