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Experimental investigation reveals end-organ dysfunction driven by gamma-secretase activating protein in bacterial pneumonia, highlighting a key mechanism of post-infection injury.
Pneumonia is a common cause of end-organ dysfunction, both during and in the aftermath of infection. In particular, pneumonia is a common cause of lung injury, increased risk of myocardial infarction, and neurocognitive dysfunction, although the mechanisms responsible for such increased risk are unknown. Here, we reveal that gamma-secretase activating protein, which contributes to the amyloidogenic pathway, is important for end-organ dysfunction following infection.
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Gwin et al. (2023) studied this question.
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