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A fraction prepared from normal human plasma inhibits the swelling of the acute carrageenan-induced paw oedema in the rat. Treatment of the animals with prostaglandin E1, arachidonic acid or with substances which either block the formation of prostaglandins or antagonize their action showed that these mediators are concerned in the development of the paw oedema. The anti-inflammatory effect of the plasma fraction in the carrageenan reaction does not involve a specific interference with the prostaglandin system. The plasma fraction is not an inhibitor of the action of SRS-A on the guinea-pig ileum.
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Smith et al. (1974) studied this question.
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