Why the study?
Persistent microcirculatory abnormalities are associated with poor clinical outcomes in circulatory shock, but identifying patients with acutely reversible microcirculatory dysfunction remains an open challenge.
Does topical nitroglycerin identify reversible microcirculatory dysfunction in patients with circulatory shock after cardiac surgery?
Does topical nitroglycerin identify reversible microcirculatory dysfunction in patients with circulatory shock after cardiac surgery?
A low-dose topical nitroglycerin challenge can safely assess for localized recruitment of microcirculatory blood flow and identify nitroglycerin responsiveness in patients with circulatory shock after cardiac surgery.
Nitroglycerin challenge may identify reversible microcirculatory dysfunction post-cardiac surgery shock; hypothesis-generating pending prospective outcome trials.
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Greenwood et al. (2022) studied this question.
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