The Diagnosis of Pheochromocytoma by Demonstration of Pressor Substances in the Urine and by Retroperitoneal Pneumography

Case Reports1 July 1954THE DIAGNOSIS OF PHEOCHROMOCYTOMA BY DEMONSTRATION OF PRESSOR SUBSTANCES IN THE URINE AND BY RETROPERITONEAL PNEUMOGRAPHYCLINTON G. WEIMAN, M.D., KENNETH BACK, B.S., PETER E. RUSSO, M.D., H. A. SHOEMAKER, Ph.D., STEWART WOLF, M.D., F.A.C.P.CLINTON G. WEIMAN, M.D.Search for more papers by this author, KENNETH BACK, B.S.Search for more papers by this author, PETER E. RUSSO, M.D.Search for more papers by this author, H. A. SHOEMAKER, Ph.D.Search for more papers by this author, STEWART WOLF, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-41-1-131 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe clinical diagnosis of pheochromocytoma in patients with sustained or paroxysmal hypertension may be suggested by history and physical examination but these are rarely conclusive. Neither are attempts to demonstrate the tumor by radiography, although plain radiograph of the abdomen, intravenous pyelography and retrograde pyelography are often helpful. Retroperitoneal pneumography1, 2has been suggested to replace the relatively difficult and hazardous perirenal air insufflation, although there have been no published reports of the demonstration of chromaffin tumors by this method. Adequate justification for operation usually depends on the results of one or more pharmacologic tests that are only moderately reliable...Bibliography1. Rivas MR: Roentgenological diagnosis. Generalized subserous emphysema through a single puncture, Am. J. Roentgenol. 64: 723, 1950. Google Scholar2. SteinbackLyonSmithMiller HLRPDRSR: Extraperitoneal pneumography, Radiology 59: 167, 1952. CrossrefMedlineGoogle Scholar3. Aranow H: Pheochromocytoma, in Monographs in medicine, Series I, edited by Bean, W. B., 1952, The Williams & Wilkins Co., Baltimore, p. 179. Google Scholar4. ShapiroBakerHoffmanFerris APHMMSEB: Pharmacologic and physiologic studies of a case of pheochromocytoma, Am. J. Med. 10: 115, 1951. CrossrefMedlineGoogle Scholar5. Lund A: Adrenaline and noradrenaline in blood and urine in cases of pheochromocytoma, Scandinav. J. Clin. and Lab. Invest. 4: 263, 1952. CrossrefMedlineGoogle Scholar6. SpragueKvalePriestley RGWFJT: Management of certain hyperfunctioning lesions of the adrenal cortex and medulla, J. A. M. A. 151: 629, 1953. MedlineGoogle Scholar7. RothKvale GMWF: A tentative test for pheochromocytoma, Am. J. M. Sc. 210: 653-660, 1945. CrossrefGoogle Scholar8. GuarneriEvans VJA: Pheochromocytoma: report of a case with a new diagnostic test, Am. J. Med. 4: 806-813, 1948. CrossrefMedlineGoogle Scholar9. EvanRubitskyBartelsBartels JAHJCCEC: Re-evaluation of the reliability of pharmacological and cold pressor studies in hypertension and pheochromocytoma, Am. J. Med. 11: 448-460, 1951. CrossrefMedlineGoogle Scholar10. LaDueMurisonPack JSPJGT: Use of tetraethylammonium bromide as diagnostic test for pheochromocytoma, Am. J. Med. 29: 914-921, 1948. AbstractGoogle Scholar11. GoldenbergSnyderAranow MCHH: New test for hypertension due to circulating epinephrine, J. A. M. A. 135: 971, 1947. CrossrefMedlineGoogle Scholar12. TaliaferroAdamsHaag IRH: Benzodioxane test, J. A. M. A. 140: 1271, 1949. CrossrefMedlineGoogle Scholar13. RothKvale GMWF: Pharmacologic tests as an aid in diagnosis of pheochromocytoma, Mod. Concepts Cardiovas. Dis. 18: 41, 1949. MedlineGoogle Scholar14. Goldenberg M: Adrenal medullary function, Am. J. Med. 10: 627-641, 1951. CrossrefMedlineGoogle Scholar15. BeyerRossWiebelhausWallerSchuchardt KHCAVDWSGS: Vasopressor components of pheochromocytomas, Ann. Int. Med. 35: 117, 1951. LinkGoogle Scholar16. Schneider RW: Chemistry and physiology of adrenal medulla: adrenal medullary syndrome: pheochromocytoma, Abstracts of lectures, Fifth Annual Postgraduate Assembly in Endocrinology and Metabolism, Lecture 17, p. 91, Nov., 1952. Google Scholar17. GrimsonLonginoKernodleO'Rear KSFHCEHB: Treatment of a patient with a pheochromocytoma, J. A. M. A. 140: 1273, 1949. CrossrefMedlineGoogle Scholar18. WilkinsGreerCulbertsonHalperinLitterBurnettSmithwick RWWEJWMHJCHRH: Extensive laboratory studies of a patient with pheochromocytoma before and after successful operation, Arch. Int. Med. 86: 51, 1950. CrossrefGoogle Scholar19. Drill VA: Reactions from the use of benzodioxane in diagnosis of pheochromocytoma, New England J. Med. 241: 777, 1949. CrossrefMedlineGoogle Scholar20. GreenPeterson DMEM: Hypertensive encephalopathy after administration of benzodioxane, J. A. M. A. 142: 408, 1950. CrossrefMedlineGoogle Scholar21. BiermanPartridge HRJW: Untoward reactions to tests for pheochromocytoma, New England J. Med. 244: 582, 1951. CrossrefMedlineGoogle Scholar22. Raab W: Adreno-sympathogenic heart disease, Ann. Int. Med. 28: 1010, 1948. LinkGoogle Scholar23. Tullon HP: Negative benzodioxane test in presence of a phaeochromocytoma, Brit. M. J. 1: 531, 1952. CrossrefMedlineGoogle Scholar24. Place VA: Piperoxan hydrochloride (benzodioxane) test, report of a false positive reaction, J. A. M. A. 146: 1227, 1951. CrossrefMedlineGoogle Scholar25. Soffer A: False positive reaction to the piperoxan hydrochloride test for pheochromocytoma, J. A. M. A. 148: 538, 1952. CrossrefMedlineGoogle Scholar26. ConleyJunkerman JECL: Lack of specificity of piperoxan hydrochloride test for adrenal medullary tumors, J. A. M. A. 147: 921, 1951. CrossrefMedlineGoogle Scholar27. Grimson KS: Discussion of Kleinsasser, L. J., Cramer, I., and Warsaw, H.: Anastomosis of the cervical esophagus: experimental evaluation of peritoneal grafts. I. Two-layer anastomosis, Surgery 28: 437, 1950. Google Scholar28. HaimoviciMedinets HH: Effect of Dibenamine on the blood pressure in normotensive and hypertensive subjects, Proc. Soc. Exper. Biol. and Med. 67: 163, 1948. CrossrefMedlineGoogle Scholar29. Aranow H: The differential diagnosis of pheochromocytoma, M. Clin. North America 34: 757, 1950. CrossrefMedlineGoogle Scholar30. WunschWarnkeMyers RERDGB: The effects of Dibenamine in severe hypertension, Ann. Int. Med. 36: 613, 1950. Google Scholar31. EmletGrimsonBellOrgain JRKSOMES: Use of piperoxan and Regitine as routine tests in patients with hypertension, J. A. M. A. 146: 1383, 1951. CrossrefMedlineGoogle Scholar32. EngelvonEuler AUS: Diagnostic value of increased urinary output of noradrenaline and adrenaline in pheochromocytoma, Lancet 2: 387, 1950. CrossrefMedlineGoogle Scholar33. BackGrinnellWeimanShoemaker KCEHCGHA: To be published. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication October 9, 1953.From the Departments of Medicine, Pharmacology and Radiology of the University of Oklahoma School of Medicine, Oklahoma City, Oklahoma. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTumoren des sympathischen NervensystemsBibliographyPheochromocytoma in childrenPheochromocytoma in the adult and in the childPHEOCHROMOCYTOMA: A CASE OF PAROXYSMAL HYPERTENSIVE ATTACKS INDUCED BY EATING AND CHANGE OF POSITION*HILLEL L. HORN, M.D.Pheochromocytoma: Report of Five Cases, One a spontaneous CurePHEOCHROMOCYTOMA ASSOCIATED WITH PAINLESS MYOCARDIAL INFARCTION*MARTIN H. BOLDT, M.D., F.A.C.P., MORRIS FLEXNER, M.D., F.A.C.P., ALVIN B. ORTNER, M.D., F.A.C.S.Paroxysmal Hypertension Due to Pheochromocytoma 1 July 1954Volume 41, Issue 1Page: 131-139KeywordsDiagnostic radiologyHypertensionIntravenous pyelographyPathologistsPharmacologyPheochromocytomaPyelographySurgeryUrine Issue Published: 1 July 1954 PDF downloadLoading ...