Abnormal forearm vascular responses in the carcinoid syndrome: the role of kinisns and kinin-generating system.

effects of bradykinin, epinephrine, methoxamine, and reflex stimulation of the sympathetic nervous system (cold pressor test) on a specific vascular bed, that of the forearm. The effects of these interventions on both the resistance and capacitance vessels were examined in normal subjects and carcinoid patients. In addition, an understanding of the pharmacodynamics of induced and spontaneous flushes was accomplished by the determination of tumor kallikrein and kinin peptide in arterial plasma and comparison of the levels of these substances with the circulatory changes observed.