Progressive brown discoloration of siliconeintraocular lenses after vitrectomy in a patient on amiodarone

A patient who was treated with amiodarone for 3 years developed brown discoloration of the intraocular lenses in both eyes. Contrast sensitivity and blue perception were reduced in the right eye. After vitrectomy for a vitreoretinal traction syndrome in the left eye, the discoloration appeared to increase. The apparent progression may have been related to breakdown of the blood-aqueous barrier after vitrectomy. However, because the discoloration developed before surgery and was bilateral, long-term administration of amiodarone may also have played a role.