Pulmonary Edema Induced by Angiotensin II in Rats

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Population

Rats with pulmonary edema induced by angiotensin I (20 microg/kg) or adrenaline (25 microg/kg)

Design

Preclinical

Authors

Discussion

Hypothesis-generating for angiotensin II in experimental pulmonary edema; leaves open human translation.

Population

Rats with pulmonary edema induced by angiotensin I (20 microg/kg) or adrenaline (25 microg/kg)

Intervention

Captopril (5, 10, and 20 mg/kg), losartan (10 mg/kg), or phentolamine (10 mg/kg)

Outcome

Development of pulmonary edemasurrogate

Angiotensin I-induced pulmonary edema in rats is mediated by angiotensin II and its specific receptor, independent of adrenaline.

Shimakura et al. (1995) studied this question.

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