Measurements of total exchangeable sodium (TENa) were made in a series of 16 patients with essential hypertension before and after marked sodium restriction. Changes in values for TENa have been compared with the net sodium balance according to estimates of intake and output of this ion. In 16 of the 44 periods included in this study, it was found that variation in TENa bore no apparent relationship to net balance calculations and, in fact, diverged significantly. It was suggested that changes in the availability of the reservoir of sodium in bone, and possibly in other tissues, accounted for the findings.
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Lewis K. Dahl (1963) studied this question.