A differential assay method has been investigated in order to distinguish tolypomycin Y from the other components which were produced simultaneously by Streptomyces tolypophorus. About 600 strains were tested for sensitivity to tolypomycin Y and the other components. It was found that the growth of Streptococcus alcalophilus IFO 3531 was inhibited by tolypomycin Y, but not by the other components. The assay method for the differentiation of tolypomycin Y from the other components was established using the paper disc method with Streptococcus alcalophilus IFO 3531.
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Tōru Hasegawa (1972) studied this question.
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